Protein Details: Potassium voltage-gated channel subfamily S member 1

Protein ID

ICDB_Pro_1399

Protein Name

Potassium voltage-gated channel subfamily S member 1

Gene Name

KCNS1

Organism

Homo sapiens (Human)

Length

526 amino acids

AlphaFoldDB

AF-Q96KK3-F1-model_v4.pdb

Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2

Sequence

MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Meningeal Melanomatosis and Central Nervous System Melanocytic Neoplasm

Location

Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain; fetal kidney and lung; and adult prostate and testis (PubMed:10484328).

DOI ID

10.1152/ajpcell.1999.277.3.c412; 10.1038/414865a; 10.1101/gr.2596504

RefSeq

NP_001309728.1; NP_002242.2